Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-07-08 · biorxiv
· doi:10.64898/2026.07.07.736975
Cawte, A. D.; Cihlova, B.; Brockdorff, N.
The MS2 system has been widely adopted for live-cell single molecule imaging of mRNA, but is of limited applicability for RNAs present in the cell nucleus due to excess nuclear-localised fluorescent capsid protein. Here we describe Nuclear-BRITE, an improved methodology that reduces nuclear background signal, enabling fast live-cell imaging of a wide range of endogenously tagged nuclear RNAs at s…
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bioRxiv (preprint)
· 2026-07-08 · biorxiv
· doi:10.64898/2026.07.07.736946
Geerlings, C.; Darmasaputra, G.; Jordan Ortiz, C.; Chuva de Sousa Lopes, S. M.; Clevers, H. M.; Galli, M.
Polyploid cells, which contain more than two copies of the genome, are widely present across plants and animals, where they are often found in tissues with high biosynthetic and metabolic demands, such as the mammalian liver and placenta. While somatic polyploidy is frequently associated with increased cell growth and biosynthetic capacity, unscheduled polyploidization in cell types that are not …
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bioRxiv (preprint)
· 2026-07-08 · biorxiv
· doi:10.64898/2026.07.02.736227
Morrow, K. T.; Karamanova, N.; Woltjer, R.; Krajbich, V.; Shu, J.; Li, M.; Tang, C.; Maerivoet, A.; Madine, J.; Chen, Y.; Migrino, R. Q.
Background: Age is the most important risk factor for coronary artery disease (CAD) independent of traditional risk factors. Aging induces classic pro-inflammatory and prothrombotic vascular phenotypic changes whose molecular mediators remain poorly understood. Medin is a common cleavage product protein that accumulates in vasculature with aging and shown to cause endothelial dysfunction. Its rol…
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bioRxiv (preprint)
· 2026-07-08 · biorxiv
· doi:10.64898/2026.07.08.736994
Cornet Gomez, A.; Peyer, N.; Zaugg, L. S.; Goveas, L.; Zivko, C.; Heverhagen, J. T.; von Tengg-Kobligk, H.; Ruprecht, N.
Background: Gadolinium-based contrast agents (GBCAs) are routinely used in magnetic resonance imaging (MRI). Although macrocyclic GBCAs were initially considered biologically inert, it is now known that a fraction of patients retains gadolinium (Gd) for prolonged periods in tissues such as blood, bone, and brain. Because the first cellular interactions of GBCAs occur in the bloodstream, this stud…
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International journal of molecular medicine
· 2026 Sep · pubmed
· doi:10.3892/ijmm.2026.5923
Yang R, Zeng H, Xiao Q, Xie Y
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International journal of molecular medicine
· 2026 Sep · pubmed
· doi:10.3892/ijmm.2026.5916
Du Y, Zhou C, Tian Y, Li Z
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Aging
· 2026 May 29 · pubmed
· doi:10.18632/aging.206386
Nishimura T, Horigome A, Tanaka M, Hishida Y
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Aging
· 2026 Jun 26 · pubmed
· doi:10.18632/aging.206392
Menard R, Madelaine R
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462406
Zhang Y, Gao Y, Luo A, Liang A
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462413
Chan AHY, Beyene K, Lai B, Kim S
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261460844
Kim S, Park SK
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Rejuvenation research
· 2026 Jul 9 · pubmed
· doi:10.1177/15491684261460820
Hao Z, Meng T, Li S, Bu Y
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Population health metrics
· 2026 Jul 9 · pubmed
· doi:10.1186/s12963-026-00491-4
Rabbi AMF, Hossain MB, Zanotto L
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Scientific reports
· 2026 Jul 9 · pubmed
· doi:10.1038/s41598-026-59567-8
Maleki M, Kalateh Jari S, Mohammadi Torkashvand A
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Ageing research reviews
· 2026 Jul 9 · pubmed
· doi:10.1016/j.arr.2026.103241
Moskalev A, Veselova O, Calabrese V, Rashan L