Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-07-10 · biorxiv
· doi:10.64898/2026.07.09.737329
Huang, X.; Bard, J. E.; Tumenbayar, B.-I.; Vedagiri, K.; Nelson, C. E.; Kenche, H.; Reynolds, C. E.; Leme, A. S.; Moore, S. J.; Perry, N. A.; Shapiro, S. D.; Perry, Y.; Bae, Y.; Blumental-Perry, A.
Proteostasis declines with lung aging, while the role of the Unfolded Protein Response (UPR) in lung aging and age-associated pulmonary diseases remains understudied. We investigated how deficiency in the UPR sensor ATF6 affects physiological and smoke exposure-accelerated lung aging. ATF6 -deficient mice exhibited accelerated alveolar simplification, a sign of lung parenchymal aging, which was e…
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bioRxiv (preprint)
· 2026-07-10 · biorxiv
· doi:10.64898/2026.07.02.735969
Coelho, P. A.; Yu, C.; Glover, D. M.
Centrosome amplification is frequently associated with chromosomal instability and tumor progression, but how cells coordinate centriole assembly with the control of centrosome numbers and quality remains poorly understood. TIAM1 is a RAC1 guanine nucleotide exchange factor previously implicated in centrosome-associated signaling and {beta}TrCP-dependent control of PLK4 abundance. Here, we examin…
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bioRxiv (preprint)
· 2026-07-10 · biorxiv
· doi:10.64898/2026.06.23.733964
Nasrashvili, T.; Emini, B.; Cirri, E.; Rahnis, N.; Poempner, N.; Gerner, C.; Grillari, J.; Heller, R.; Kaether, C.
Cellular senescence is characterized by stable cell cycle arrest and the senescence-associated secretory phenotype (SASP), which drives tissue remodeling and inflammation. Underlying SASP with its increased secretion of cytokines and other secreted proteins is a massive reorganization of the secretory pathway. While transcriptional regulation of senescence has been extensively studied, the contri…
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bioRxiv (preprint)
· 2026-07-10 · biorxiv
· doi:10.64898/2026.07.02.733740
Del Carmen-Fabregat, A.; Oswal, N.; Sinha, K.; Vicencio, J.; Abramowitz, R.; Eder, M.; Begik, O.; Sedlackova, L.; Novoa, E. M.; Stroustrup, N.
The abundance of mRNA sets a ceiling on a cells capacity to produce protein and carry out its functions. Here, we describe a pathological decline in absolute mRNA abundance that occurs in most cell types during invertebrate and mammalian aging, caused by decreases in mRNA synthesis capacity. In C. elegans, decreases in mRNA abundance are tightly coupled to declines in RNA Polymerase II (Pol II) p…
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bioRxiv (preprint)
· 2026-07-10 · biorxiv
· doi:10.64898/2026.07.04.736531
Ding, Z.; Shi, Y.; Liu, H.; Li, C.; Chen, J.; Cohen-Solal, M.; Kusumbe, A. P.
High-resolution 3D imaging is an important strategy for visualizing and analysing complex skeletal tissue architecture and the bone marrow microenvironment. However, multicolor immunolabeling and imaging of intact skeletal tissues are technologically challenging. The current immunolabeling and clearing methods for intact skeletal elements are very limited, time-consuming and generate low-resoluti…
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JPRAS open
· 2026 Sep · pubmed
· doi:10.1016/j.jpra.2026.05.041
Bohórquez JMC, Wan J, Wong IKJ, Green JB
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Aging
· 2026 May 29 · pubmed
· doi:10.18632/aging.206386
Nishimura T, Horigome A, Tanaka M, Hishida Y
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Aging
· 2026 Jun 26 · pubmed
· doi:10.18632/aging.206392
Menard R, Madelaine R
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462406
Zhang Y, Gao Y, Luo A, Liang A
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462413
Chan AHY, Beyene K, Lai B, Kim S
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261460844
Kim S, Park SK
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Rejuvenation research
· 2026 Jul 9 · pubmed
· doi:10.1177/15491684261460820
Hao Z, Meng T, Li S, Bu Y
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Aging
· 2026 Jul 8 · pubmed
· doi:10.18632/aging.206398
Lorente ABL, Vazquez S, Iwasaki K, Adebayo A
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Aging
· 2026 Jul 6 · pubmed
· doi:10.18632/aging.206395
Flora Y, Shastri D, DeLeo KR, Bohnert KA
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BMC psychology
· 2026 Jul 11 · pubmed
· doi:10.1186/s40359-026-05166-1
Skurvydas A, Dadeliene R, Aukstikalnis T, Istomina N