Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-07-16 · biorxiv
· doi:10.64898/2026.07.15.738587
Jiang, X.; Li, H.; Jiang, L.; Cao, C.; Jiang, Q.; Su, N.; Fang, M.; Chen, Z.; Zuo, F.; Zhao, Y.; Tian, X.; Chen, X.; Zhu, L.; Yang, Y.
Fluorescent RNAs (FRs) have emerged as powerful tools for the visualization of RNA in live cells. However, the poor folding of FRs is a major limiting factor in many advanced RNA imaging applications. Here, we describe a novel strategy to significantly increase the folding efficiency of FRs. By introducing a stabilizing stem and performing targeted mutagenesis at key junction regions, we develop …
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bioRxiv (preprint)
· 2026-07-16 · biorxiv
· doi:10.1101/2025.06.16.659752
Garrod-Ketchely, C.; Callender, L. A.; Schroth, J.; Littlewood, K.; Carroll, E. C.; Tamsan, D.; Tsang, V. S.; Nessel, I.; Riddell, N. E.; Chain, B.; Harding, D.; Marelli-Berg, F. M.; Bystrom, J.; Pereira Da Costa, M.; Carrascal-Minino, A.; Keeling, G. P.; Pham, T. T.; Sunassee, K.; De Rosales, R. T.; Terry, S. Y.; Pattrick, M.; Sutcliffe, C.; Worthington, A.; Hood, G.; Finer, S.; Henson, S. M.
Ageing is associated with significant immune changes, with unhealthy ageing characterised by chronic inflammation and immune dysregulation. Here we identify a population of CD8 TEMRA cells during unhealthy ageing, which exhibit features of premature senescence and are regulated in part by TGF{beta}. These cells show impaired cytotoxic function and altered tissue distribution pattern, including an…
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bioRxiv (preprint)
· 2026-07-16 · biorxiv
· doi:10.64898/2026.07.15.738680
Tang, X.; Gao, J.; Wang, H.; Wei, X.; Zhou, X.; Pan, X.; Wang, Y.; Li, M.; Li, Q.
Bacillus subtilis is a core microbial chassis in biomanufacturing, and establishing efficient gene editing technologies is key to engineering this strain. In conventional CRISPR gene editing technologies, the large size of DNA nucleases leads to difficulties in plasmid construction, low transformation efficiency, and cumbersome multi-round editing operations; therefore, developing miniature gene …
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JPRAS open
· 2026 Sep · pubmed
· doi:10.1016/j.jpra.2026.05.041
Bohórquez JMC, Wan J, Wong IKJ, Green JB
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Rejuvenation research
· 2026 Jun 8 · pubmed
· doi:10.1177/15491684261449703
Devi R, Shukla D, Kumar V, Upadhayay S
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462406
Zhang Y, Gao Y, Luo A, Liang A
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462413
Chan AHY, Beyene K, Lai B, Kim S
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Rejuvenation research
· 2026 Jul 9 · pubmed
· doi:10.1177/15491684261460820
Hao Z, Meng T, Li S, Bu Y
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Aging
· 2026 Jul 8 · pubmed
· doi:10.18632/aging.206404
Chang WT, Shih JY, Lin YW, Huang TL
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Aging
· 2026 Jul 8 · pubmed
· doi:10.18632/aging.206398
Lorente ABL, Vazquez S, Iwasaki K, Adebayo A
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Biomedical engineering online
· 2026 Jul 18 · pubmed
· doi:10.1186/s12938-026-01604-8
Xie P, Jiang F
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Clinical epigenetics
· 2026 Jul 17 · pubmed
· doi:10.1186/s13148-026-02206-w
Feng J, Liang Y, Zhou J, Yu Y
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BMC geriatrics
· 2026 Jul 17 · pubmed
· doi:10.1186/s12877-026-07988-5
Ren Y, Yang J, Peng J, Xi X
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BMC geriatrics
· 2026 Jul 17 · pubmed
· doi:10.1186/s12877-026-07929-2
Kumagai Y, Ahmad I, Shimizu C, Shirayama Y
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Annals of neurology
· 2026 Jul 17 · pubmed
· doi:10.1002/ana.78299
Low A, Gunter JL, Hu M, Raghavan S