Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-07-17 · biorxiv
· doi:10.64898/2026.07.15.732710
Jain, A.; Li, J.; Yu, X.; Opejin, A.; Yu, D.; Trapp, A.; Tumiel, J.; Chiang, Z.; Pastrana, E.; Polanco, C.; Pachas, J.; Lopez, F.; Pulido, M.; Carapia, B.; Deshmukh, S.; Vavilina-Halstead, A.; Sevilla, A.; Dabbah, M.; Karthikeyan, S.; Shindyapina, A.
Hematopoietic stem cell (HSC) function declines with age, contributing to immunosenescence and inferior transplantation outcomes. Here, we generated iPSC-derived HSCs (iHSCs) from multiple adult donors and performed integrated epigenetic, transcriptional, telomeric, and functional analyses to see if they retain youthful identity across differentiation and serial transplantation. Longitudinal DNA …
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bioRxiv (preprint)
· 2026-07-17 · biorxiv
· doi:10.64898/2026.07.16.736849
Yan, B.; Han, J.; Yang, Y.; Zhang, P.; Brant, J. O.; Chang, J.; Kim, H.-N.; Almeida, M.; Kaur, P.; Yuan, Q.; Demaria, M.; Shirlekar, K.; Elisseeff, J.; Zheng, G.; Liang, Y.; Zhou, D.; Guryanova, O. A.
Aging of the hematopoietic system impairs hematopoietic stem cell (HSC) function and alters bone marrow niche behavior, increasing susceptibility to anemia, infections, and hematologic malignancies. Here, pharmacologic clearance of senescent cells with the PROTAC compound 753b simultaneously targeting BCL-xL and BCL-2 reverses key secretory, transcriptional, and functional hallmarks of hematopoie…
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bioRxiv (preprint)
· 2026-07-17 · biorxiv
· doi:10.64898/2026.07.16.738981
Zhan, T.; Gerstner, N. C.; Martin, J. G.; McCann, J. T.; Lynch, M. C.; Wu, H.-J.; Xu, K.; Miller, E. W.
We report a generalizable method for single-molecule localization super-resolution microscopy in living cells. Live-cell protein-based PAINT (points accumulation for imaging in nanoscale topography) is achieved by pairing exceptionally fluorogenic bis-trifluoromethyl rhodamine (BF) dyes with reversible HaloTag ligands. This far-red small molecule update to protein-based PAINT is readily incorpora…
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bioRxiv (preprint)
· 2026-07-17 · biorxiv
· doi:10.64898/2026.07.16.738626
Policet-Betend, H.; Jorda-Siquier, T.; Cuenu, G.; Badre, M.; Schranz, S.; Da Costa, J.; Brockmann, C.; Senn, P.; Huber, D.; Lamy, C. M.
Human anatomy has traditionally been studied using low-resolution approaches such as cadaveric dissection and conventional medical imaging, limiting our understanding of macroscopic structures. Tissue clearing has emerged as a transformative approach, enabling three-dimensional mapping of organs at microscopic resolution, and offering the opportunity to interrogate anatomy across scales. However,…
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bioRxiv (preprint)
· 2026-07-17 · biorxiv
· doi:10.64898/2026.07.14.738581
Dwaraka, V. B.; Melnikas, M.; Hassouneh, S. A.-D.; Rosko, A.; Presley, C. J.; Aparicio, A.; Smith, R.; Lasky-Su, J.; Burd, C. E.
Blood-based DNA methylation is widely used as a molecular surrogate for traits ranging from circulating protein and metabolite levels to biological aging, but whether the CpGs driving these models reflect genuine gene regulation or statistical convenience is unresolved. Training elastic-net models using the expression of 77 T cell genes across 333 matched T-cell enriched blood samples, we show th…
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JPRAS open
· 2026 Sep · pubmed
· doi:10.1016/j.jpra.2026.05.041
Bohórquez JMC, Wan J, Wong IKJ, Green JB
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Rejuvenation research
· 2026 Jun 8 · pubmed
· doi:10.1177/15491684261449703
Devi R, Shukla D, Kumar V, Upadhayay S
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462406
Zhang Y, Gao Y, Luo A, Liang A
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462413
Chan AHY, Beyene K, Lai B, Kim S
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Rejuvenation research
· 2026 Jul 9 · pubmed
· doi:10.1177/15491684261460820
Hao Z, Meng T, Li S, Bu Y
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Aging
· 2026 Jul 8 · pubmed
· doi:10.18632/aging.206404
Chang WT, Shih JY, Lin YW, Huang TL
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Aging
· 2026 Jul 8 · pubmed
· doi:10.18632/aging.206398
Lorente ABL, Vazquez S, Iwasaki K, Adebayo A
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Reviews on environmental health
· 2026 Jul 20 · pubmed
· doi:10.1515/reveh-2025-0181
Devi B, Raj P
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Journal of cardiothoracic surgery
· 2026 Jul 18 · pubmed
· doi:10.1186/s13019-026-04493-z
Chen J, Gao Y, Liu F, Li Y
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Journal of ovarian research
· 2026 Jul 18 · pubmed
· doi:10.1186/s13048-026-02202-x
Li X, Wang Z, Zhang X, Wang H