Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-07-20 · biorxiv
· doi:10.64898/2026.07.17.739205
Lovejoy, M.; Rabino, A. F.; Gonzalez-Blotta, L.; Gangasani, V.; Durham, S. M.; Kreider, G.; Garcia-Mata, R.
Polarized epithelia are essential for organ function, and disruption of epithelial polarity is a hallmark of many diseases, including cancer. We previously showed that the RhoG-specific guanine nucleotide exchange factor SGEF interacts with the Scribble polarity complex to regulate epithelial junction assembly in 2D monolayers. However, its role in epithelial morphogenesis and lumen formation in …
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bioRxiv (preprint)
· 2026-07-20 · biorxiv
· doi:10.64898/2026.07.19.739388
Ji, J.; Kim, Y.; Han, E.; Choi, Y.; Park, J.; Lee, H.; Park, S.; Son, A.; Kim, H.
Aging is characterized by progressive physiological decline, yet the molecular mechanisms underlying these changes remain incompletely understood. Although extensive work has examined age-related alterations in protein abundance, the age-dependent structural reorganization of proteins and their interaction networks remains largely unexplored. Here, we quantitatively characterize the structural dy…
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bioRxiv (preprint)
· 2026-07-20 · biorxiv
· doi:10.64898/2026.07.13.738343
Bai, F.; Chua, K.; Li, D. Y.; Kirillova, A.; Yadav, S.; Staudt, D. W.; Yamamoto, Y.; De Jong, H. N.; Müller, L. H.; Fenzl, K.; Rungaramsin, N.; Huang, Y.; Reuter, C.; Zhang, S.; Krysov, V. A.; Njoroge, J. N.; Floyd, B.; Lakdawala, N. K.; James, C. A.; Cannie, D. E.; Elliott, P. M.; Mestroni, L.; Owens, A. T.; Merlo, M.; Krahn, A. D.; Mao, C.; Fatkin, D.; Vedantham, V.; Chahal, A. A.; Wu, J. C.; MacRae, C. A.; Gotthardt, M.; Roden, D. M.; Roth, F. P.; Ashley, E. A.; Meder, B.; Kroncke, B. M.; Tabet, D. R.; Cote, A. G.; Steinmetz, L.; Glazer, A. M.; Mercola, M.; Parikh, V. N.
The promise of precision therapeutics in genetic cardiomyopathies relies on linking specific therapies to variant mechanisms. Missense variants in the cardiac splice regulator RBM20 cause a highly penetrant and arrhythmogenic dilated cardiomyopathy. Disease-causing variants in RBM20's arginine-serine rich (RS) domain act via formation of toxic gain of function cytoplasmic granules, but this is no…
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bioRxiv (preprint)
· 2026-07-20 · biorxiv
· doi:10.64898/2026.07.14.738381
Han, X.; Wang, X.; Yang, L.; Ma, L.; Wu, H.; Wang, R.; Guo, G.
Single-nucleus RNA-seq (snRNA-seq) offers advantages in sample preparation for atlas construction and data mining of gene regulation. However, current snRNA-seq protocols struggle to balance sensitivity and throughput. Here we present ultra-throughput and ultra-sensitivity single-nucleus total RNA sequencing (UURNA-seq), a platform that enables large-scale atlas construction in a single day. UURN…
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bioRxiv (preprint)
· 2026-07-20 · biorxiv
· doi:10.64898/2026.07.15.724605
Lee, M. E.; Kim, J.; Ionita, M.; McKeague, M.; Lee, J.; Nam, Y.; Jeong, C.-U.; Nair, A.; Moyo, E. T.; Khavin, I.; Wang, K.; Shwetank, ; Mathew, D. E.; Fang, V.; Fensterheim, B. A.; Pattekar, A.; Rangwala, Z.; Bar-Or, A.; Abramoff, B. A.; Rhee, R.; Schuster, S.; Huang, A. C.; Meyer, N.; Levy, M.; Garfall, A.; Bhoj, V.; Kaminski, M.; Naji, A.; Yang, E.; Cabanski, C.; Connolly, J.; Guercio, L.; Wagenaar, J.; Baxter, A. E.; Maseda, D.; Apostolidis, S. A.; Painter, M. M.; Vonderheide, R. H.; Greenplate, A. R.; Kim, D.; Wherry, E. J.
The human immune system is composed of [~]30-50 distinct cell types, each of which can exist in different states of activation or differentiation. Indeed, the mammalian immune system has evolved to sense and respond to infections, cancers, injuries, and changes in tissue or host homeostasis (1). Moreover, an increasingly large fraction of approved drugs target the immune system directly, and/or c…
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bioRxiv (preprint)
· 2026-07-20 · biorxiv
· doi:10.64898/2026.07.17.735408
Baca, G. L.; Monticone, R.; Ziman, B.; Rahman, S. M. T.; Parekh, P.; Afrin, S.; Dunn, C.; Telljohan, R.; Yang, D.; Lam, K. W. G.; Killeen, P.; Tsitsipatis, D.; Zagrean, A.-M.; Sung, M.-H.; Greig, N.; Herman, A. B.; Sen, P.; de Cabo, R.; Lakatta, E. G.
Approximately half of the adult sinoatrial node (SAN) consists of non-myocyte populations, indicating that cardiac pacemaking depends on interactions within a multicellular tissue rather than on pacemaker cardiomyocytes alone. Among these, an S100B-associated cell population has been implicated in pacemaker function, yet its identity and physiological roles remain poorly understood. These cells a…
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JPRAS open
· 2026 Sep · pubmed
· doi:10.1016/j.jpra.2026.05.041
Bohórquez JMC, Wan J, Wong IKJ, Green JB
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Rejuvenation research
· 2026 Jun 8 · pubmed
· doi:10.1177/15491684261449703
Devi R, Shukla D, Kumar V, Upadhayay S
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462406
Zhang Y, Gao Y, Luo A, Liang A
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Rejuvenation research
· 2026 Jun 17 · pubmed
· doi:10.1177/15491684261462413
Chan AHY, Beyene K, Lai B, Kim S
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Rejuvenation research
· 2026 Jul 9 · pubmed
· doi:10.1177/15491684261460820
Hao Z, Meng T, Li S, Bu Y
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Aging
· 2026 Jul 8 · pubmed
· doi:10.18632/aging.206404
Chang WT, Shih JY, Lin YW, Huang TL
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Aging
· 2026 Jul 8 · pubmed
· doi:10.18632/aging.206398
Lorente ABL, Vazquez S, Iwasaki K, Adebayo A
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Proceedings of the National Academy of Sciences of the United States of America
· 2026 Jul 28 · pubmed
· doi:10.1073/pnas.2600323123
Wang X, Yang J, Jin C, Wang X
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Proceedings of the National Academy of Sciences of the United States of America
· 2026 Jul 28 · pubmed
· doi:10.1073/pnas.2603231123
Guan H, Mao L, Fang F, Wu T