Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-09-20 · biorxiv
· doi:10.64898/2026.09.14.751594
Hu, R.; Sanchez-Velasquez, J.; Lou, J.; Breslin, K.; Cameron, T.; Solano, A.; Wickramasinghe, I.; Gouil, Q.; Kueh, A. J.; Willson, T.; Keniry, A.; Geoghegan, N. D.; Hinde, E.; Blewitt, M. E.
Chromatin proteins play critical roles in gene regulation, yet frequently we do not fully understand how weak DNA binding affinity of such proteins contributes to their locus-specific actions. Here, we studied SMCHD1, a non-canonical SMC-family protein involved in three-dimensional genome organization and gene repression of the inactive X chromosome and its autosomal targets. We replaced endogeno…
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bioRxiv (preprint)
· 2026-09-19 · biorxiv
· doi:10.64898/2026.09.14.750622
Kontopoulou, M.; Xenophontos, M.; Lederer, C. W.; Stephanou, C.; Kountouris, P.
Background Given the augmented sampling and ancestry stratification of the Genome Aggregation Database (gnomAD) v4.1 compared to v2.1.1, population evidence for globin gene variants was assessed for changes in the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) criteria fulfillment, which can alter downstream variant interpretation. Methods…
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bioRxiv (preprint)
· 2026-09-19 · biorxiv
· doi:10.64898/2026.09.17.752120
Sayettat, S.; Tolksdorf, F.; Johannson, R.; Nelke, J.; Malz, A.; Fischer, L.; Gerhard, I.; Ullrich, N.; Ellinghaus, U.; Stadler, C. R.; Bogen, J. P.; Morin, C.; Knüfer, J.; Stumpf, R.; Schommers, P.; Sahin, U.; Seaman, M. S.; Kratochvil, S.; Klein, F.; Le Douce, V.; Gruell, H.
Recombinant broadly neutralizing antibodies (bNAbs) are promising tools to treat and prevent HIV-1 infection but are associated with manufacturing challenges. To overcome this limitation, we encoded the potent bNAb 1-18-LS on RNA (1-18-LS RibobNAb) for delivery via lipid nanoparticles (LNPs). Indicating high in vivo antibody expression, a 30 ug RNA-LNP intravenous injection resulted in an average…
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Plant physiology
· 2026 Sep 21 · pubmed
· doi:10.1093/plphys/kiag704
Lee SJ, Min WK, Song JT, Seo HS
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Plant physiology
· 2026 Sep 21 · pubmed
· doi:10.1093/plphys/kiag697
Calzadilla PI, Brusslan J
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Expert review of respiratory medicine
· 2026 Sep 20 · pubmed
· doi:10.1080/17476348.2026.2736322
Thanh Tung N, Tran XN, Chang JH, Chuang HC
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Brain, behavior, and immunity
· 2026 Sep 20 · pubmed
· doi:10.1016/j.bbi.2026.107023
Seitz-Holland J, Haaf M, Mendes-Silva AP, Penzel N
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Mechanisms of ageing and development
· 2026 Sep 20 · pubmed
· doi:10.1016/j.mad.2026.112258
Li X, Fu Z, Sun D, Jin Z
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Experimental eye research
· 2026 Sep 20 · pubmed
· doi:10.1016/j.exer.2026.111242
Huo R, Chang N, Bergersen LH
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Ageing research reviews
· 2026 Sep 20 · pubmed
· doi:10.1016/j.arr.2026.103378
Lu R, Cui YY
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Pest management science
· 2026 Sep 20 · pubmed
· doi:10.1002/ps.71314
Zhu XY, Wei JL, Tariq H, Xu J
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Odontology
· 2026 Sep 20 · pubmed
· doi:10.1007/s10266-026-01560-8
Machado AA, Back LS, de Souza Melo G, Gruber R
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Aging
· 2026 Sep 16 · pubmed
· doi:10.18632/aging.206422
Zhavoronkov A, Mishra B
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Aging
· 2026 Sep 16 · pubmed
· doi:10.18632/aging.206415
Rijt SV, Denis SW, Butter LM, Schomakers BV
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Aging
· 2026 Sep 12 · pubmed
· doi:10.18632/aging.206421
Temprado JJ, Sleimen-Malkoun R