Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-09-29 · biorxiv
· doi:10.1101/2020.08.11.245688
Fujiwara, Y.; Kabuta, C.; Contu, V. R.; Ogawa, M.; Fujita, H.; Kikuchi, H.; Sakai, R.; Suzuki, M.; Koyama-Honda, I.; Inoue, M.; Oya, Y.; U. Inoue, Y.; Inoue, T.; Takahashi, R.; Matsumoto, G.; Matoba, K.; Noda, N. N.; Nishino, I.; Wada, K.; Fujimoto, T.; Noguchi, S.; Kabuta, T.
Constitutive lysosomal degradation of cytosolic proteins is fundamental to proteostasis, but how these substrates are delivered into the lysosomal lumen remains incompletely understood. In mammals, the contribution of microautophagy to basal lysosomal protein degradation and the molecular machinery that mediates this process remain poorly defined. Here we identify a mammalian microautophagic path…
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bioRxiv (preprint)
· 2026-09-29 · biorxiv
· doi:10.64898/2026.09.28.754972
Doerner, K.; Kurth, K.; Beuret, N.; Beer, N.; Jones, M. K.; Davey, K.; Stadelmann, L.; Huegli, D.; Ferrand, A.; Basile, G.; Luescher, S.; Ule, J.; Voigt, F.; Hondele, M.
Cells must prevent incompletely spliced transcripts from entering the cytoplasm, yet how splicing status is recognized and converted into selective nuclear retention remains unclear. Here, we identify a network of RNA-binding proteins that retain pre-mRNPs within nuclear speckles. Proteomic analysis of splicing intermediates accumulated in nuclear speckles identified a set of retention factors in…
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bioRxiv (preprint)
· 2026-09-29 · biorxiv
· doi:10.64898/2026.09.17.752374
Zhang, G.; Wang, G.; Cao, R.; Guo, J.; Xu, S.; Yu, Z.; Zheng, Y.; He, Y.; Feng, X.
Three-dimensional (3D) cell morphology provides a measurable phenotype of cellular state and function, yet learning transferable and interpretable morphological representations across biological systems and imaging modalities remains challenging. Here we introduce MorphCell, a self-supervised framework that learns shape-driven representations from cell-surface point clouds through cross-view reco…
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bioRxiv (preprint)
· 2026-09-29 · biorxiv
· doi:10.64898/2026.09.23.753472
Perret, M.; Anzeraey, A.; Aujard, F.
Early environmental conditions can have long-lasting effects on survival and reproductive fitness. Using a 23 year-long monitoring data set of captive mouse lemur's life history traits, we tested a relationship between maternal allocation to offspring (N = 1365) and their adulthood survival. Maternal characteristics such as age or body condition did not affect allocation to offspring whatever the…
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Gerodontology
· 2026 Sep 30 · pubmed
· doi:10.1111/ger.70125
Yonezawa Y, Asano A, Kuwajima Y, Sato H
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Pest management science
· 2026 Sep 30 · pubmed
· doi:10.1002/ps.71364
Reinhold LM, Traynor KS
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Nature aging
· 2026 Sep 30 · pubmed
· doi:10.1038/s43587-026-01226-8
Ying K, Bie J, Chen G, Cuervo AM
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Oral diseases
· 2026 Sep 30 · pubmed
· doi:10.1111/odi.70369
Zhu M, Zhang C, Zhang Y, Zhang C
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Advances in wound care
· 2026 Sep 30 · pubmed
· doi:10.1177/21621918261490101
Pitcher LE, Zhu J, Schmidt EL, Niedernhofer LJ
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Journal of materials science. Materials in medicine
· 2026 Sep 30 · pubmed
· doi:10.1007/s10856-026-07115-1
Geão C, Costa-Pinto AR, Cunha-Reis C, Ribeiro VP
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Trends in molecular medicine
· 2026 Sep 30 · pubmed
· doi:10.1016/j.molmed.2026.09.006
Li Y, Zhao D, Cui W
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International journal of biological macromolecules
· 2026 Sep 30 · pubmed
· doi:10.1016/j.ijbiomac.2026.154686
Pandey G, Kolipaka T, Yadav D, Arya DK
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Biomedical materials (Bristol, England)
· 2026 Sep 30 · pubmed
· doi:10.1088/1748-605X/aeae96
Xu Y, Zhong W, Cheng W, Zhou X
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Biomedical materials (Bristol, England)
· 2026 Sep 30 · pubmed
· doi:10.1088/1748-605X/aeae95
Ghanavati Z, Farokhi M, Koeini F, Akbari Laleh M
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Current medicinal chemistry
· 2026 Sep 29 · pubmed
· doi:10.2174/0109298673474262260909061628
Shaikh AN, Ginayatova I, Malikova I, Kriajevska M