Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-10-07 · biorxiv
· doi:10.64898/2026.10.05.756875
Wang, Y.; Patil, T.; Neal, S.; Jenie, I. K. S.; Ignatoff, E.; Bintu, B.; Lyons, D.
Cell type diversification during development is often attributed to differential gene transcription. Here, we show that, during Crepidula atrasolea embryogenesis, transcriptomically distinct cell types arise through differential distribution of pre-existing mRNAs. Combining immunofluorescence, live imaging, and whole-mount 3D spatial transcriptomics (MERFISH) of over 40 embryos, we show that many…
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bioRxiv (preprint)
· 2026-10-07 · biorxiv
· doi:10.64898/2026.10.06.757022
zhang, s.; Kutibiding, A.; Wang, M.; yang, y.
Abstract Background Migrasomes, the newly discovered vesicular organelles, have long been speculated to originate from membrane dynamics during cell migration. Here we present integrated imaging and multi-omics evidence supporting a ciliary origin of migrasomes. The shared vesicular trafficking pathways between ciliogenesis and migrasome biogenesis (trans-Golgi/endosomal systems) prompted us to i…
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bioRxiv (preprint)
· 2026-10-07 · biorxiv
· doi:10.64898/2026.10.06.754136
Domkam, N.; Yerima, G.; Tsukamoto, S.; Mofrad, M.
The LINC (linker of nucleoskeleton and cytoskeleton) complex is a central mechanotransductive apparatus that physically couples cytoskeletal forces to the nuclear interior, thereby regulating nuclear architecture, chromatin organization, and downstream signaling. Using atomistic molecular dynamics simulations, we identify and characterize force gates within the LINC complex, structural interactio…
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bioRxiv (preprint)
· 2026-10-07 · biorxiv
· doi:10.64898/2026.01.24.701460
Yang, Y.; Hess, P. R.; Chen, X. E.; Huang, S.; Teneche, M. G.; Wang, H.; Miller, K. N.; Davis, A. E.; Miciano, C.; Li, K. Y.; Mamde, S.; Yip, K.; Ren, B.; Yang, Q.; Smoot, E.; Wang, A.; Johnson, B.; Huang, A. C.; Wilson, P.; Adams, P. D.; Zhang, N. R.
Aging reshapes tissues through changes in cellular composition, coordinated transcriptional reprogramming, and loss of transcriptional coordination. Whereas the first two have been characterized across aging tissues, the third remains difficult to quantify. We introduce an unsupervised, first-principles framework for measuring transcriptional dyscoordination in single cells as deviation from a le…
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bioRxiv (preprint)
· 2026-10-07 · biorxiv
· doi:10.64898/2025.12.22.696095
Solar, S. J.; Hebbar, P.; de Lima, L. G.; Sweeten, A. P.; Rhie, A.; Potapova, T. A.; de Gennaro, L.; Guarracino, A.; Kim, J.; Pickett, B. D.; Paten, B.; Wilson, M. A.; Koren, S.; Garrison, E.; Eichler, E. E.; Ventura, M.; Gerton, J. L.; Phillippy, A. M.
The short arms of human acrocentric chromosomes are characterized by nucleolar organizer regions essential for ribosome biogenesis, but their highly repetitive nature has hindered genomic analysis. Leveraging the recently completed genomes of all major great ape lineages, we identified recurrent features of their acrocentrics, including enriched repeat classes, centromere repositioning by whole-a…
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Dental materials : official publication of the Academy of Dental Materials
· 2026 Oct 8 · pubmed
· doi:10.1016/j.dental.2026.10.003
Tu S, Dong H, Liu J, Liang R
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Trends in endocrinology and metabolism: TEM
· 2026 Oct 8 · pubmed
· doi:10.1016/j.tem.2026.09.012
Sharma J, Kumari M, Mathew SJ
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Orthopaedic surgery
· 2026 Oct 8 · pubmed
· doi:10.1111/os.70451
Wang Y, Zhao X, Wang K, Liu Z
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Experimental gerontology
· 2026 Oct 8 · pubmed
· doi:10.1016/j.exger.2026.113352
Elmi F, Azizsoltanti A, Taghizadeh M, Eslaminejad MRB
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Journal of affective disorders
· 2026 Oct 8 · pubmed
· doi:10.1016/j.jad.2026.122601
Chung HS, Namgung M, Lee DH, Choi YH
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BMJ (Clinical research ed.)
· 2026 Oct 8 · pubmed
· doi:10.1136/bmj-2026-101072
Smith R
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Ageing research reviews
· 2026 Oct 8 · pubmed
· doi:10.1016/j.arr.2026.103408
Yang Z, Sun H, Zhang F, Ji W
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Neurochemical research
· 2026 Oct 8 · pubmed
· doi:10.1007/s11064-026-04909-1
Ramírez-López AB, Avilez-Avilez JJ, Gómez-González B, Salas-Venegas V
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Molecular biology reports
· 2026 Oct 8 · pubmed
· doi:10.1007/s11033-026-12792-w
Lanlan L, Fan G, Ran Z, Xiaoqing Z
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eLife
· 2026 Oct 8 · pubmed
· doi:10.7554/eLife.111498
Deng F, Yang R, Niu J, Wang M