Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-10-18 · biorxiv
· doi:10.64898/2026.10.13.758751
Perciato, M. L.; Davies, M.; Akhbari, P.; Denise, H.; Clauss, A.; Cole, S. L.; Haas, K. M.; Lee, B.; Jouy, C.; Ballihaut, C.; Lee, B. P.; Harries, L. W.
Cellular senescence is a driver of skin ageing that leads to structural deterioration and aesthetic changes. This study evaluated a novel senomorphic strategy, using synergistic combinations of natural small molecules to target RNA splicing regulation via upstream ERK/AKT signaling pathways. Nature-identical synthetic molecules, and corresponding extracts were assessed for cytotoxicity, impact on…
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bioRxiv (preprint)
· 2026-10-18 · biorxiv
· doi:10.64898/2026.10.12.758456
Koohy, H.; Ilievski, I.; Antanaviciute, A.; Ogg, G.
T cells are at the centre of adaptive immunity, protecting the organism against infection and cancer. T cell receptors (TCRs), expressed on the surface of T cells, enable the recognition of target cells through interactions with peptides presented by major histocompatibility complex (pMHC) molecules. Reliable, large-scale mapping of TCRs to their cognate pMHCs remains a holy grail of modern syste…
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bioRxiv (preprint)
· 2026-10-18 · biorxiv
· doi:10.64898/2026.10.12.758663
Qin, R. Z.; Abberger, H.; Man, G.; Broomfield, B. J.; Williams, B. E.; Tan, C. W.; Duckworth, B. C.; Jenkins, M. R.; Geoghegan, N. D.; Rogers, K. L.; Tuong, Z. K.; Groom, J. R.
Recent discoveries have identified human tumor tertiary lymphoid structures (TLS) as organized clusters of innate and adaptive immune cells and stromal cells. Cancer-associated TLS can promote tumor clearance and enhance responses to immune checkpoint blockade (ICB) immunotherapy. However, the absence of TLS in conventional mouse tumor models, particularly subcutaneous transplant models, limits e…
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bioRxiv (preprint)
· 2026-10-18 · biorxiv
· doi:10.64898/2026.10.12.758644
Gottschlich, A.; Kavaka, V.; Janert, T. A.; Igl, V.; Carlini, E.; Rohrbacher, L.; den Hartog, W.; Harwood, J.; Trefny, M. P.; Sogukcelik, S.; Penovici, P.; Ransmayr, B.; Rausch, C.; Brauneck, F.; Frenz-Wiessner, S.; Goek, I.; Haenel, G.; Zucchinetti, C.; Oner, A.; Zwicker, P. S.; Gruenmeier, R.; Delahais, S.; Schnell, P. M.; Nandi, S.; Thomas, M.; Brabenec, R.; Briukhovetska, D.; Michaelides, S.; Mueller, R. D.; Ballheimer, L. Y.; Tsiverioti, C. A.; Hoffmann, G. V.; Stock, S.; Piseddu, I.; Mueller, P. J.; Kruppa, M.; Fiedler, W.; Rade, M.; Kreuz, M.; Kehl, N.; Bhagwat, A. S.; Thiel, J. T.; Ste
Immunotherapy in acute myeloid leukemia (AML) is constrained by a hostile bone marrow niche. Here we identify atypical memory B cells (Batyp) as a suppressive population within this microenvironment. Across single cell and flow cytometry cohorts, Batyp were expanded in AML, and their molecular and phenotypic profiles resembled those of atypical B cells associated with chronic inflammatory conditi…
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bioRxiv (preprint)
· 2026-10-18 · biorxiv
· doi:10.64898/2026.10.12.758563
Rodriguez-Gutierrez, H. F.; Jainarayanan, A.; Tosolini, M.; Aslani, F.; Iscache, A.-L.; Müller, S.; Corre, B.; Vanazzi, A.; Elanchezhian, M.; Laurent, C.; Valitutti, S.; Khazen, R.
Cytotoxic T lymphocytes (CTLs) eliminate infected or malignant cells through repeated target-cell encounters, yet how they sustain cytotoxic activity during extended antigenic stimulation remains poorly understood. In particular, it remains unclear whether preserved population-level killing reflects maintenance of a uniform effector phenotype or diversification into functionally distinct CTL popu…
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bioRxiv (preprint)
· 2026-10-17 · biorxiv
· doi:10.64898/2026.10.11.751335
Amaya-Ramirez, D. A.; Florez-Suarez, J. B.; Mora-Fonseca, J. D.; Parra-Lopez, C. A.
Personalized neoantigen based vaccines have progressed from concept to clinical evidence for some of the most aggressive human tumors, yet a key challenge remains: determining which candidates should be prioritized for vaccine inclusion. Public neoantigens, shared across tumor subtypes and patient populations, offer potential as off the shelf candidates for broad spectrum immunotherapy. Candidate…
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JBJS essential surgical techniques
· 2026 Oct-Dec · pubmed
· doi:10.2106/JBJS.ST.26.00004
Lonner BS, Kurapatti M, Dolgopolov S, Youssef G
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Annals of African medicine
· 2026 Oct 19 · pubmed
· doi:10.4103/aam.aam_911_26
Lobo CW, Ponraj RR, Singh R, Lobo SA
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Drug and chemical toxicology
· 2026 Oct 18 · pubmed
· doi:10.1080/01480545.2026.2726177
Goenka S
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Ageing research reviews
· 2026 Oct 18 · pubmed
· doi:10.1016/j.arr.2026.103423
Bérubé M, Linsotan S, Gauthier L, Godwin B
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Experimental gerontology
· 2026 Oct 18 · pubmed
· doi:10.1016/j.exger.2026.113363
Speiser JL, Falvey JR, Houston DK, Cawthon PM
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Environmental pollution (Barking, Essex : 1987)
· 2026 Oct 18 · pubmed
· doi:10.1016/j.envpol.2026.129370
Feng Z, Duan Y, Bai B, Wei X
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Advanced science (Weinheim, Baden-Wurttemberg, Germany)
· 2026 Oct 18 · pubmed
· doi:10.1002/advs.78287
Li S, Miao Z, Wong TW, Li T
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Advanced healthcare materials
· 2026 Oct 18 · pubmed
· doi:10.1002/adhm.71868
Wang Z, Chang H, Zhang Y, Gan Y
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Advanced science (Weinheim, Baden-Wurttemberg, Germany)
· 2026 Oct 18 · pubmed
· doi:10.1002/advs.78123
Zhao L, Zhang X, Ren Q, Song X