Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-10-19 · biorxiv
· doi:10.64898/2026.10.16.759663
Martinez, J. C. C.; Kim, S. J.; Cutting, J.; Sedivy, J. M.; Seluanov, A.; Gorbunova, V.
The cGAS-STING pathway is a major driver of chronic inflammation. While acute STING inhibition can reduce neuroinflammation and tissue damage, its long-term impact on longevity remains unknown. Here, we demonstrate that genetic deletion of STING extends median lifespan in mice. This survival benefit is accompanied by a marked resistance to age-related hepatic decline. Our findings demonstrate tha…
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bioRxiv (preprint)
· 2026-10-19 · biorxiv
· doi:10.64898/2026.10.15.759434
Patel, A. K.; Ganesh, N.; Arya, V.; Kapopara, P. R.; Rathinavel, G.; Arige, V.; Mahapatra, N. R.
Cystathionine gamma-lyase (CTH), a key enzyme in hydrogen sulfide (H2S) biosynthesis, has been studied extensively in models of oxidative stress. Dysregulated CTH has been reported in cardiovascular disease, ischemia-reperfusion (I/R) injury, aging, and xenobiotic stress, where reactive oxygen species are central to pathology. Despite this, how CTH is regulated at the molecular level under basal,…
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ACS applied materials & interfaces
· 2026 Oct 21 · pubmed
· doi:10.1021/acsami.6c18179
Wang J, Kuang T, Hu B, Yin J
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Autoimmunity reviews
· 2026 Oct 20 · pubmed
· doi:10.1016/j.autrev.2026.104198
Guo H, Xiang W, Zeng L, Xiao W
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Bulletin of mathematical biology
· 2026 Oct 20 · pubmed
· doi:10.1007/s11538-026-01775-4
Buescu J, Elaydi SN, Oliveira HM
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Cancer letters
· 2026 Oct 20 · pubmed
· doi:10.1016/j.canlet.2026.218902
Xiao R, Hong JH, Wang P, Zhong Y
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Toxicology and applied pharmacology
· 2026 Oct 20 · pubmed
· doi:10.1016/j.taap.2026.118088
Huang P, Pang X, Wang Z, Li X
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Odontology
· 2026 Oct 20 · pubmed
· doi:10.1007/s10266-026-01586-y
Wu Y, Li B, Yang Z
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ACS applied bio materials
· 2026 Oct 20 · pubmed
· doi:10.1021/acsabm.6c01206
Du S, Navarrete-Segado P, Sevostianova V, Patterson J
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British journal of clinical pharmacology
· 2026 Oct 20 · pubmed
· doi:10.1002/bcp.70870
A RN, Sathiamoorthy K, Karthick Rajan P, Rajendran P
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Plastic and reconstructive surgery
· 2026 Oct 20 · pubmed
· doi:10.1097/PRS.0000000000013549
Mahmoud AA, Fijany A, Copeland-Halperin L, Wong G
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Trends in cancer
· 2026 Oct 20 · pubmed
· doi:10.1016/j.trecan.2026.09.010
Li Z, Wang H, Diao M, Liu R
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Journal for immunotherapy of cancer
· 2026 Oct 20 · pubmed
· doi:10.1136/jitc-2026-016538
Gao X, Wang Q, Zhang Z, He F
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Journal for immunotherapy of cancer
· 2026 Oct 20 · pubmed
· doi:10.1136/jitc-2026-015974
Jie G, Cao Z, Wang J, Lu W
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Cancer letters
· 2026 Oct 20 · pubmed
· doi:10.1016/j.canlet.2026.218905
Dong Z, Huang W, Zhang L, Guo Q