Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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Bioactive materials
· 2027 Mar · pubmed
· doi:10.1016/j.bioactmat.2026.10.009
Deshmukh K, Pandey M, Moulahoum H, Ghorbanizamani F
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bioRxiv (preprint)
· 2026-10-29 · biorxiv
· doi:10.64898/2026.05.05.722960
Choi, M.; Ravishankar, R.; He, L.; Yan, Y.; Kreider, G. J.; Xu, P.; Lee, D. E.; Danuser, G.; Hahn, K. M.
Fluorescent biosensors that report protein conformation in vivo have been invaluable for understanding how the spatio-temporal dynamics of signaling controls cells. However, for GTPases these biosensors report the activated conformation using reagents that block the binding of downstream proteins, generating dominant negative effects and altering normal cell physiology. We present here a generali…
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bioRxiv (preprint)
· 2026-10-29 · biorxiv
· doi:10.64898/2025.12.22.695963
Boshar, S.; Evans, B.; Tang, Z.; Adel, Y.; Bornachot, Y.; Sidbon, S.; Lorbeer, F. K.; Picard, A.; Rajesh, C.; Seitz, E.; Emms, D.; Mendoza-Revilla, J.; Hernandez, A.; Al-Ani, F.; Karch, T.; Schiff, Y.; Lopez, M.; Laterre, A.; Beguir, K.; Koo, P.; Kuleshov, V.; Stark, A.; de Almeida, B. P.; Pierrot, T.
Comparative genomics and synthetic biology require models that can interpret, annotate, and design DNA sequences across species, yet genomic models have not combined these capabilities beyond a few well-characterized organisms. Here we introduce Nucleotide Transformer v3 (NTv3), a long-context cross-kingdom foundation model that provides a common backbone for functional prediction, gene annotatio…
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bioRxiv (preprint)
· 2026-10-29 · biorxiv
· doi:10.64898/2026.10.26.761778
Lacy, M. S.; Binenbaum, Y.; Buenzli, P. R.; Jenner, A. L.
Adoptive T cell therapy is a promising field in cancer immunotherapy that leverages the natural ability of T cells to target and kill cancer cells. A crucial step in this therapy involves the ex vivo expansion of memory-like and effector-like T cells, but limiting their differentiation into exhaustion-associated phenotypes remains a challenge. Mathematical model-informed strategies to optimise T …
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bioRxiv (preprint)
· 2026-10-29 · biorxiv
· doi:10.1101/2025.02.12.637990
Chu, C. M. J.; Kamal, S.; Huang, H.; Bayly, C. L.; Beletsky, M. J.; Mar, S.; Chen, S.-Y.; Omur, M. E.; Wasserman, W. W.; Lynn, F. C.; Johnson, J. D.
Stem cell-derived {beta}-like cells (SC{beta} cells) are an alternative to cadaveric {beta} cells for replacement therapy in type 1 diabetes. However, SC{beta} cells face a multitude of stresses. Both {beta} cells and SC{beta} cells reside in complex microtissues and are modulated by hundreds of autocrine/paracrine signals. Here, we leveraged multi-omics data from late-stage SC{beta} cells and hu…
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bioRxiv (preprint)
· 2026-10-29 · biorxiv
· doi:10.64898/2026.10.27.761507
Craddock, R. F.; Janes Fistric, M.; Mellersh, C.; Ilska, J. J.; Wiener, P.; Smith, S.; Gorjanc, G.
Background Most monogenic inherited diseases in dogs are recessive, so their successful control depends on genetic testing to identify carriers of the disease-causing allele. However, currently used methods for disease allele monitoring in canine populations typically only consider part of the entire pedigree, since not all dogs have a known genotype through genetic test or "hereditary status" (a…
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Cardiovascular research
· 2026 Oct 31 · pubmed
· doi:10.1093/cvr/cvag239
Zhou R, Yang Y, Qiao J, Yang Y
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Journal of community health nursing
· 2026 Oct 30 · pubmed
· doi:10.1080/07370016.2026.2754466
Sacchetti A, Bellier A, Pison C, Berube M
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Interactive journal of medical research
· 2026 Oct 30 · pubmed
· doi:10.2196/76500
Zamudio F, Arauna D, Garcia F, Albala C
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The Journal of investigative dermatology
· 2026 Oct 30 · pubmed
· doi:10.1016/j.jid.2026.10.022
Tilley L, Shwartz Y
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Plant molecular biology
· 2026 Oct 30 · pubmed
· doi:10.1007/s11103-026-01772-0
Chen F, Zhang Y, Wu Z, Zhang H
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Journal of global health
· 2026 Oct 30 · pubmed
· doi:10.7189/jogh.16.04317
Wang W, Wang Y, Hu X, Chen F
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Archives of biochemistry and biophysics
· 2026 Oct 30 · pubmed
· doi:10.1016/j.abb.2026.111045
Wang M, Li F, Liang Y, Su L
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Experimental gerontology
· 2026 Oct 30 · pubmed
· doi:10.1016/j.exger.2026.113370
Liu Y, Ma Y, Liu Y, Sun Z
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Current biology : CB
· 2026 Oct 30 · pubmed
· doi:10.1016/j.cub.2026.10.009
Xu H, Song Q, Mamo W, Tolosa LN