Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-11-02 · biorxiv
· doi:10.64898/2026.05.11.724403
Sitarska, E.; Saminathan, A.; Scanavachi, G.; Somerville, E.; Stock, P.; Shen, P.; Kahne, D.; Courtney, M. F.; Reid, D. A.; Danielsen, M. B.; Davidsen, F. K. N.; Jensen, K. J.; Bennett, F. C.; Kirchhausen, T.
Phosphorothioate-modified antisense oligonucleotides (ASOs) enter cells, but their site of productive escape remains uncertain. We combined live-cell imaging and ratiometric pH measurements to follow a Malat1-targeting ASO internalized without a delivery vehicle. In U2OS cells, less than 4% of internalized ASO reached the nucleus under conditions that reduced Malat1 RNA by >90%. Most ASO accumula…
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bioRxiv (preprint)
· 2026-11-01 · biorxiv
· doi:10.64898/2026.10.27.760067
Burger, B.; Sagiorato, R. N.; Baccarin, I. B.; Munoz, V. R.; Cerna, G.; Andreev, I.; Araujo, N.; Shu, H. S.; Zhao, J.; Sullivan, B.; Liang, Y.; Bistaffa, R. A. M.; Gaspar, V. C.; Yabuuti, E. M.; Ramos, N. B.; Pral, L. P.; Evavold, C.; Filho, J. C. A.; Varga-Weisz, P.; Serezani, C. H. C.; Vinolo, M. A. R.; Silva, H. M.; Rodrigues, H. G.
Psoriasis is associated with altered lipid metabolism, including reduced expression of fatty acid metabolism genes and decreased circulating oleic acid. Here we report that oral oleic acid supplementation normalized serum oleic acid levels and protected from skin thickening and epidermal hyperplasia in a imiquimod mice model of psoriasis. These effects were associated with preserved skin-resident…
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bioRxiv (preprint)
· 2026-11-01 · biorxiv
· doi:10.64898/2026.10.27.762224
Wijshake, T.; Rose, J.; Jun, J. H.; Zielke, J.; Li, L.; Takahashi, J. S.; Rijo-Ferreira, F.; Agathocleous, M.
Infections stimulate myelopoiesis but this comes at the cost of reduced production of other lineages. It is unclear if this imbalance is protective or damaging, and if factors that promote balanced hematopoiesis can impact infection pathology. Here we show that the ascorbate-TET axis limits excessive myelopoiesis, promotes balanced hematopoiesis, and is essential for surviving malaria. Hematopoie…
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bioRxiv (preprint)
· 2026-11-01 · biorxiv
· doi:10.1101/2025.08.31.673173
Levy, T.; Anselmi, C.; Ishizuka, K. J.; Gordon, T.; Voskoboynik, Y.; McGeever, E.; Detweiler, A. M.; Levin, L.; Palmeri, K. J.; Liu, D. D.; Sinha, R.; Ohene-Gambill, B. F.; Raveh, T.; Morri, M.; Vanni, V.; Manni, L.; Sahoo, D.; Neff, N. F.; Rosental, B.; Weissman, I. L.; Voskoboynik, A.
Germline stem cells (GSCs), the source of gametes, are the only stem cells capable of passing genes to future generations making them cellular units of natural selection. Yet, factors regulating their fitness, and thus governing GSC competition, which exist in both protochordates and mammals, remain poorly understood. We study how aging affects GSC fitness in the protochordate Botryllus schlosser…
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bioRxiv (preprint)
· 2026-11-01 · biorxiv
· doi:10.64898/2026.05.11.724381
Byrne, J.; Martin, N.; Watson, M. A.; Soygur, B.; Devrukhkar, P. R.; Tran, T.; Shanes, E.; Pavone, M. G.; Duncan, F.; Schilling, B.
The postmenopausal ovary is commonly viewed as a largely quiescent organ, yet its cellular biology remains incompletely characterized. We generated a single-nucleus atlas of the aging postmenopausal human ovary comprising 439,011 nuclei across 64 ovarian samples from 28 donors. We resolved 37 cell states, revealing extensive stromal, vascular, and immune heterogeneity. We developed an interactive…
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bioRxiv (preprint)
· 2026-11-01 · biorxiv
· doi:10.1101/2025.07.13.664578
Cleary, J. H.; Sackheim, A. M.; Sonawane, R.; Seitz, T.; Walters, B.; Wentzel, K. J.; Howard, A. J.; Sheeser, L. N.; Barba, R.; Piffard, S. H.; Benson, J. C.; Trebak, M.; Shea, S. M.; Neal, M. D.; Mohapatra, N.; Wang, A.; Kornblith, L. Z.; Cohen, M. J.; Yaffe, M. B.; Majumdar, D.; Hennig, G.; Nelson, M. T.; Freeman, K.
**Background:** Extracellular histones released after trauma and in sepsis injure the vascular endothelium and contribute to coagulopathy and organ failure. Hypocalcemia frequently accompanies resuscitation with citrated blood products and predicts poor outcome, an association usually attributed to coagulation-factor dysfunction. Whether extracellular Ca2+ directly governs endothelial vulnerabili…
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Aging
· 2026 Oct 20 · pubmed
· doi:10.18632/aging.206430
Sottas PE
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Aging
· 2026 Oct 20 · pubmed
· doi:10.18632/aging.206434
Ventura L, Cano A, Morrone M, Martinez G
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International psychogeriatrics
· 2026 Nov 2 · pubmed
· doi:10.1016/j.inpsyc.2026.100308
Zheng DD, Lee DJ, Curiel RE, Rundek T
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The Laryngoscope
· 2026 Nov 2 · pubmed
· doi:10.1002/lary.71033
Liu LX, Vasudevan SS, Hawkins A, Rengifo D
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Frontiers in neuroendocrinology
· 2026 Nov 2 · pubmed
· doi:10.1016/j.yfrne.2026.101294
Thurston LT, Galper M, Taghdisi D, Walsh RJ
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Journal of the American Academy of Dermatology
· 2026 Nov 2 · pubmed
· doi:10.1016/j.jaad.2026.10.100
Fleshner L, Burshtein J, Sayegh A, Gadula S
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Biology of reproduction
· 2026 Nov 2 · pubmed
· doi:10.1093/biolre/ioag245
O'Donnell EC, Lim J, Das A
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Journal of economic entomology
· 2026 Nov 2 · pubmed
· doi:10.1093/jee/toag322
Jyothimallapura Kempegowda P, Kamanur M
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Journal of controlled release : official journal of the Controlled Release Society
· 2026 Nov 2 · pubmed
· doi:10.1016/j.jconrel.2026.115504
Jiang Y, Li S, Liehn EA, Chan CS