Últimas 48 h · PubMed · Europe PMC · bioRxiv · incluye Aging-US y Rejuvenation Research vía PubMed
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bioRxiv (preprint)
· 2026-11-04 · biorxiv
· doi:10.64898/2026.11.02.763800
Renganathan, B.; Moore, A. S.; Adam, S. A.; Lippincott-Schwartz, J.; Gelfand, V. I.
Vimentin intermediate filaments (VIFs) undergo active microtubule-dependent transport throughout the cell, with trajectories resembling those of motor-driven organelles, yet our recent work showed that only a small subset of VIFs lies close to microtubules. How VIFs engage the microtubule-based transport machinery, and whether additional transport routes contribute, remain unresolved. We hypothes…
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bioRxiv (preprint)
· 2026-11-04 · biorxiv
· doi:10.64898/2026.11.02.763799
Clarke, J.; Wu, F.; Janbandhu, V.; Bagot, S.; Zheng, D.; Puccetti, P. M.; Cheng, D.; Zhuang, X.; Maksura, H. E.; Zhang, X.; Rajal, A. G.; Feng, J.; Tran, Y.; Pinto, A. R.; Koo, P. K.; Cox, C. D.; Harvey, R. P.; Jones, L. W.; Tammela, T.; Wong, E. S.
Aging profoundly alters the genome's regulatory landscape, but the properties of age-acquired enhancers, including how they are selected and sustained in aged animals are unclear. We used single-cell multiomics in the mouse heart to identify age-responsive cis-regulatory elements and endurance exercise to understand which of these elements can be attenuated. Aging increased AP-1 engagement at mor…
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bioRxiv (preprint)
· 2026-11-04 · biorxiv
· doi:10.64898/2026.11.03.763605
Shanta, T. B.; Nguyen, N. T. K.; Raja, E.; Ishikawa, M.; Habib, A. G. K.; Oinam, L.; Yanagisawa, H.; Tateno, H.; Sada, A.
Glycosylation of cell-surface proteins plays several essential roles in cell-matrix interactions and receptor signaling, thereby contributing to tissue homeostasis and aging. In aged mouse skin, epidermal stem cells exhibit increased levels of a2,6-sialylated complex-type N-glycans alongside upregulation of glycogenes such as St6gal1 and Man1a; however, the functional importance of these glycosyl…
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bioRxiv (preprint)
· 2026-11-04 · biorxiv
· doi:10.64898/2026.11.03.763791
Yang, M. M.; Auyeung, V. C.; Kim, S. M. C.; Flynn, E.; Naikawadi, R. P.; Bazarov, A. V.; Lea, A.; Deiter, F.; Neely, J.; Kukreja, J.; Matthay, M. A.; Jones, K. D.; Greenland, J. R.; Sirota, M.; Wolters, P. J.
Rationale: Interstitial lung disease (ILD) drives mortality in systemic sclerosis (SSc), with a subset developing progressive pulmonary fibrosis (PPF) resembling idiopathic pulmonary fibrosis (IPF). Despite recognition of two distinct histopathologic patterns, the cellular basis of nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP) remains poorly understood. Objectiv…
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bioRxiv (preprint)
· 2026-11-04 · biorxiv
· doi:10.64898/2026.11.02.759677
Fernandez-Golbano, I. M.; Huguet, L.; Alvarez, D.; Gari, I.; Trillo, O.; Cheng, S. I.; Rebollo, E.; Geli, M. I.
Specialized endoplasmic reticulum (ER) subdomains termed ER sterol exit sites (ERSES), transiently contact endocytic sites to locally supply sterols, which in turn initiate actin polymerization and drive membrane invagination. Osh2, an oxysterol-binding protein (OSBP)-related protein (ORP), mediates the non-vesicular sterol transfer at ER-endocytic contact sites (ER-ECS). In search for additional…
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bioRxiv (preprint)
· 2026-11-04 · biorxiv
· doi:10.64898/2026.11.01.763412
Pischedda, S.; Gomez Carballa, A.; Martinon-Torres, F.; Salas, A.
Can epigenomic signatures of exceptional longevity transcend species boundaries? By comparing findings from a previously published epigenomic study of Jonathan, a 194-year-old giant tortoise, based on buccal scrape and saliva samples, with the analyses of publicly available DNA methylation data from exceptionally long-lived humans based on peripheral blood mononuclear cells (PBMCs), this comparat…
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Journal of gerontological social work
· 2026 Nov 5 · pubmed
· doi:10.1080/01634372.2026.2758613
Mei B, Homchampa P, Jullamate P
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The Journal of prosthetic dentistry
· 2026 Nov 5 · pubmed
· doi:10.1016/j.prosdent.2026.10.006
Mosaddad SA, Tavahodi N, Hosseinpour S, Ioannidis A
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Toxicology mechanisms and methods
· 2026 Nov 5 · pubmed
· doi:10.1080/15376516.2026.2748390
Kumar SN, Kubota N, Yanagita S
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Metabolism: clinical and experimental
· 2026 Nov 5 · pubmed
· doi:10.1016/j.metabol.2026.156823
Martinez de Morentin PB, Leeson-Payne A, Mu S, Martynova Y
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Experimental gerontology
· 2026 Nov 5 · pubmed
· doi:10.1016/j.exger.2026.113379
La Grotta R, Pellegrini V, Metallo A, Matacchione G
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Molecular biology reports
· 2026 Nov 5 · pubmed
· doi:10.1007/s11033-026-13050-9
Singh B, Chaturvedi MM, Purohit JS
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Herz
· 2026 Nov 5 · pubmed
· doi:10.1007/s00059-026-05397-3
Li L, Schunkert L, Schunkert H
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mBio
· 2026 Nov 5 · pubmed
· doi:10.1128/mbio.00893-26
Cypess RH, Simione FP Jr
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Nanoscale
· 2026 Nov 5 · pubmed
· doi:10.1039/d6nr02345b
M N, Siddharth G, Varma MKR, Mandal B